Tdap Vaccine: When To Get It Side Effects And Safety
Tetanus, diphtheria, and pertussis are infectious bacterial diseases. Without treatment, they can lead to severe complications, and in some instances, they are fatal. The Tdap vaccine protects against all three diseases.
The Tdap vaccine is highly effective. Since the introduction of vaccines, cases of diphtheria and tetanus have dropped by 99% , while cases of pertussis have dropped by 80%.
Doctors can give Tdap as a primary immunization or as a booster vaccine, meaning it tops up the immunity a person already has to an illness.
In this article, we will discuss what the Tdap vaccine is, how safe it is, who should get it, and possible side effects.
Tdap is a booster vaccine. It protects people from the following illnesses.
When To Seek Medical Help
Tetanus is an emergency. If a person has a wound that may have come into contact with the bacteria, they should receive medical care.
Any wound that has been exposed to a contaminant such as dirt, feces, or manure requires medical attention.
Sufficient wound care is key in preventing tetanus it is important to disinfect all wounds as soon as possible.
Tetanus is a serious bacterial infection that can be fatal. Various vaccines provide immunity against the bacteria, though this protection is temporary.
The bacteria are common in the environment, so
What Happens If I Miss A Dose Of The Whooping Cough Vaccine
If your child misses one of the five doses of the whooping cough vaccine, speak with your healthcare provider. Your child may be able to get the vaccine at their next healthcare appointment.
Teenagers who miss the Tdap booster should get it at their next visit with a healthcare provider. Likewise, adults who have never gotten the pertussis vaccine or have missed a dose should get the Tdap shot at their next healthcare provider appointment.
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Vaccines For Adults: Here Is What You Need To Know
UAB experts discuss vaccines that adults need to protect themselves and others.Protection from some childhood vaccines can wear off over time, which is why experts from the University of Alabama at Birmingham recommend adults stay on top of their immunizations to help prevent themselves from getting and spreading serious diseases.
Vaccines are one of the most convenient and safest preventive care measures available, said Sumayah Abed, M.D., assistant professor in the UAB Department of Family and Community Medicine and family medicine physician at UAB Medicine Hoover Primary and Specialty Care. Since immunity gained from vaccines can wear off over time, booster doses are necessary for adults to stimulate the immune system during adulthood. In addition to boosters, there are also other vaccines adults need to get as they age to help protect themselves and others from infectious diseases.
The Centers for Disease Control and Prevention recommends vaccines for adults based on their age, prior vaccinations, health, lifestyle, occupation, travel destinations and sexual activity but everyones needs may be different based on these factors.
Vaccines are safe and effective, Abed said. However, depending on the type of vaccine and health conditions of the recipients, some vaccines may not be recommended for everyone. That is why it is important to speak with your health care provider about your specific needs to determine the best vaccines for you.
Flu vaccine
COVID vaccine
Immunogenicity Efficacy And Effectiveness

Immunogenicity
Immunologic correlates of protection against pertussis are not well-defined, but higher levels of anti-pertussis antibodies seem to be associated with greater protection. In general, acellular pertussis-containing combination vaccines have demonstrated good immunogenicity of their component antigens. Consistently high response to pertussis vaccine has been observed after booster vaccination. Early third trimester Tdap vaccination in pregnancy leads to efficient transplacental transfer of vaccine-derived antibodies to the infant which persist until the infant may begin to be immunized at 2 months of age.
Efficacy and effectiveness
The vaccine efficacy following the primary series with acellular pertussis vaccines is estimated to be about 85%, and approximately 90% following booster immunization. Although the duration of protection afforded by acellular pertussis vaccine is unknown, available data suggests that protection does not significantly decline between the first booster and second booster with an acellular pertussis vaccine. However, a progressive decline in protection has been observed following the second booster dose. Tdap immunization in pregnancy is estimated to provide protection against pertussis in 9 of 10 infants less than 3 months of age.
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What Are The Side Effects
Most children dont have any side effects from DTaP or Tdap. The side effects that do occur are usually mild, and may include:
- Redness, swelling, or pain where the shot was given
More serious side effects are very rare but with DTaP can include:
- A fever over 105 degrees
- Nonstop crying for 3 hours or more
Some preteens and teens might faint after getting Tdap or any other shot.
To prevent fainting and injuries related to fainting, adolescents should be seated or lying down during vaccination and remain in that position for 15 minutes after the vaccine is given.
Prepare for your child’s vaccine visit and learn about how you can:
- Research vaccines and ready your child before the visit
- Comfort your child during the appointment
- Care for your child after the shot
At What Age Should I Get The Whooping Cough Vaccine
When you initially get the vaccine and how often you get it after that will depend on your age:
- Preteens and teens: Preteens and teens should receive their Tdap booster shot at age 11 or 12.
- Adults: Adults who were not vaccinated as teens can receive their Tdap at any time.
- Pregnant people: The CDC recommends that pregnant people receive their Tdap vaccine between weeks 27-36 of each pregnancy.
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What Are The Side Effects And Risks Of Tdap And Td
Like all medicines, vaccines can have side effects. However, the chance of a life-threatening reaction is small. The CDC says the dangers of developing pertussis, tetanus, or diphtheria far outweigh the risks of vaccination.
Mild side effects of Tdap may include:
- Pain, redness, or swelling in the arm where the shot was given
Mild side effects of Td may include:
- Pain, redness, or swelling in the arm where the shot was given
In some people, these side effects may be more intense. They may temporarily interfere with daily activities. Severe swelling of the arm has been reported in three out of 100 people receiving either Tdap or Td. About one in 250 adults who receive the Tdap vaccine develop a fever of 102 F or higher.
During clinical trials of Tdap, two adults developed temporary nervous system problems. It’s unknown whether this was due to the vaccine or not. In rare cases, vaccination with Tdap or Td has led to extreme swelling of the arm where the shot was given.
Preparations Authorized For Use In Canada
Pertussis-containing vaccines
- ADACEL®, Sanofi Pasteur Ltd.
- ADACEL®-POLIO , Sanofi Pasteur Ltd.
- BOOSTRIX® , GlaxoSmithKline Inc.
- BOOSTRIX®-POLIO , GlaxoSmithKline Inc.
- INFANRIX®-IPV , GlaxoSmithKline Inc.
- INFANRIX®-IPV/Hib , GlaxoSmithKline Inc.
- INFANRIX hexaTM® , GlaxoSmithKline Inc.
- PEDIACEL® , Sanofi Pasteur Ltd.
- QUADRACEL® , Sanofi Pasteur Ltd.
In Canada, pertussis vaccine is only available as an acellular preparation in a combination vaccine. The amount of acellular pertussis antigen present varies by product. Preparations containing higher concentrations of acellular pertussis antigen are administered for primary immunization of infants and young children less than 7 years of age and may be administered as a booster for children 4 years to less than 7 years of age. Preparations containing a lower concentration may also be administered as a booster dose to children 4 years to less than 7 years of age and are the recommended product for older children, adolescents and adults .
For complete prescribing information, consult the product leaflet or information contained within Health Canada’s authorized product monographs available through the Drug Product Database. Refer to Table 1 Contents of Immunizing Agents Available in Canada in Part 1 for a list of all vaccines available for use in Canada and their contents.
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Who Needs Tdap And Td Vaccines
The Centers for Disease Control and Prevention recommends Tdap vaccine for everyone starting at age 11 or 12 years. CDC recomends booster shots using Td or Tdap vaccine through adulthood.
One dose of Tdap vaccine is recommended for:
- Children age 7 to 10 years who did not get all 5 doses of DTaP vaccine.
- Children age 11 to 18 years .
- Pregnant people need Tdap vaccine during each pregnancy, By getting this vaccine, pregnant people develop immunity to protect their baby against whooping cough, and pass some protection on to the baby. The best time for pregnant people to get the vaccine is as early as possible between 27 and 36 weeks of gestation .
Who Shouldnt Get The Whooping Cough Vaccine
You should not receive a pertussis vaccine if youre allergic to any ingredient in the vaccine or have had a serious reaction to diphtheria, tetanus, or whooping cough vaccines in the past.
Before you receive your whooping cough vaccine, let your healthcare provider know if you:
- Have had a previous reaction to vaccines
- Have seizures or other nervous system problems
- Have had Guillain-Barre syndrome
If youre not feeling well, it might be a good idea to wait until you’re better to get your vaccine.
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Is It A Live Vaccine
Nope. Diphtheria, pertussis, and tetanus vaccines arent live vaccinations.
Types of vaccines that arent live include:
- inactivated vaccines, which contain microbes killed by chemicals, heat, or radiation
- subunits, which contain only part of the microbe
- toxoids, which contain inactivated toxins
- conjugate, which contains a subunit linked to a toxoid
Since the Tdap vaccine isnt live, it cant cause these diseases.
How Can I Learn More

- Ask your health care provider.
- Visit the website of the Food and Drug Administration for vaccine package inserts and additional information at www.fda.gov/vaccines-blood-biologics/vaccines.
- Contact the Centers for Disease Control and Prevention :
- Call 1-800-232-4636 or
- Visit CDC’s website at www.cdc.gov/vaccines.
Vaccine Information Statement
Tdap Vaccine
8/6/2021
Department of Health and Human Services
Centers for Disease Control and Prevention
Many vaccine information statements are available in Spanish and other languages. See www.immunize.org/vis
Hojas de información sobre vacunas están disponibles en español y en muchos otros idiomas. Visite www.immunize.org/vis
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Who Should Get Tdap Around A Newborn
The Tdap or DTaP vaccine protects against tetanus, diphtheria, and pertussis . The DTaP vaccine is given to children from 2 months to 7 years old, and the Tdap is a booster given to children 7 and older, teens, and adults. Tdap boosters are given every 10 years.
Recommended for: If you’ve never received a Tdap , get the vaccine. You also need a Tdap booster if you haven’t had one in the past 10 years.
Get the shot at least two weeks before having contact with an infant, to give your body a chance to develop antibodies to the disease after your vaccination.
Why: Parents and siblings are the most common sources of whooping cough infection in infants, so it’s important that everyone in the household have up-to-date vaccinations. Grandparents, caregivers, and friends can also transmit it.
While tetanus and diphtheria are rare in the United States today, whooping cough remains dangerous. It’s a very contagious respiratory illness, and infants are especially vulnerable because they can’t start their Tdap vaccinations until they’re 2 months old. Infants are at risk for developing serious complications from whooping cough, including pneumonia, seizures, brain damage, and death.
Vaccine Effectiveness In Children
Pertussis-containing vaccines protect against severe and typical pertussis. They provide substantially less protection against milder coughing illness.30,31DTPa vaccines with 3 or more antigens have vaccine efficacy of:31
- 7178% for preventing milder symptoms of pertussis
- 84% for preventing typical disease
The 1st dose of the childhood schedule significantly reduces the incidence of severe pertussis disease in young infants.1,73-75 Protection increases further with the doses given at 4 and 6 months of age, as measured by hospitalisation rates and mortality.
Duration of immunity in children
Immunity after receiving a pertussis-containing vaccine wanes over time. In Australian children aged 13 years who had not had an 18-month booster dose, the effectiveness of 3 doses of pertussis-containing vaccine declined progressively from 2 years of age, to less than 50% by 4 years of age.3 Studies in older children suggest that vaccine effectiveness decreases with time since the dose of pertussis-containing vaccine given before starting school.7,8,71
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Cost Of A Tdap Vaccine
The cost of the vaccine is covered under most private insurance plans. Be sure to check with your insurance provider for details. You can also check with your state health departments or local health centers for low-cost or free vaccinations.
Tdap vaccines are also covered under Medicare part D plans. There may be a cost associated with your specific plan, though, so check with your Medicare representative.
depending on your age and vaccination history:
- Ages 11 to 12 years: 1 dose Tdap
- Pregnancy: 1 dose Tdap during each pregnancy, preferably anytime between 27 to 36 weeks
Who Should Avoid Getting The Tdap Vaccine
Although the risk of having a severe allergic reaction to a Tdap vaccine is very low, certain people should avoid getting the Tdap vaccine, including:
- people who have had a previous life threatening allergic reaction to any vaccine containing tetanus, diphtheria, or pertussis
- people who were in a coma or had seizures within 7 days of a childhood dose of DTP or DTaP, or a previous dose of Tdap
- anyone under the age of 7 years old
Talk with your doctor if you have seizures or another condition that affects the nervous system.
Also, let your doctor know if youve ever had Guillain-Barré syndrome or if youve ever experienced severe pain or swelling after any previous vaccine containing diphtheria, tetanus, or pertussis.
A healthcare professionals office such as a pediatrician, family practitioner, or community health clinic is usually the best place to receive a Tdap vaccine.
These vaccines may also be available for adults at:
- health departments
- other community locations, such as schools and religious centers
You can also reach out to federally funded health centers as well as your state health department to learn where to get a vaccine near you.
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Which Vaccines Do Older Adults Need
As you get older, a health care provider may recommend vaccinations, also known as shots or immunizations, to help prevent certain illnesses.
Talk with a doctor or pharmacist about which of the following vaccines you need. Make sure to protect yourself as much as possible by keeping your vaccinations up to date.
How Could My Child Get Tetanus
Stepping on nails or other sharp objects is one way people are exposed to the bacteria that cause tetanus. These bacteria are in the environment and get into the body through breaks in the skin.
Tetanus is different from other vaccine-preventable diseases because it does not spread from person to person.
Tetanus bacteria are found in soil, dust, and manure. It gets into the body through breaks in the skin, including:
- Punctures, cuts, or sores on the skin
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Is The Tdap Vaccine Safe During Pregnancy
Yes, the Tdap vaccine is safe for both you and your baby during pregnancy. You may experience some minor side effects, including soreness at the site of the shot, redness, body aches, headaches, mild fever, nausea, chills and tiredness. You cannot get whooping cough, tetanus or diphtheria from the vaccine.
Serious reactions such as fainting, severe pain and bleeding are exceedingly rare.
Flu Vaccine For Adults Around Babies

Babies younger than 6 months are at high risk of serious flu complications but are too young to receive a flu vaccine. Heres how to protect the baby from flu:
- Before the baby is born, the mother should get a flu shot while she is pregnant to protect herself from the flu and protect the baby from flu illness for the first several months after birth, when they are too young to get vaccinated.
- Everyone who cares for the baby should get vaccinated during each flu season.
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Who Should Not Get A Pertussis Vaccine
Some people may need to wait to get vaccines. If you or your child has a mild illness, such as a cold, you still may be able to get the vaccine. If you have a more severe illness, you may need to wait until you recover.
If you are not a good candidate for a pertussis vaccine, your healthcare provider will give you instructions and information about vaccination options. In general, people should talk to their healthcare provider if they have:
- Guillain-Barré syndrome, a rare disorder where your immune system attacks your nerves.
- History of serious allergic reactions to pertussis vaccines.
- History of severe pain, fever above 105 degrees Fahrenheit or swelling after a pertussis vaccine.
- Seizures or other nervous system diseases.
- Severe allergies to any vaccine ingredients.
Should I Get A Tetanus Booster During Pregnancy
Yes. Pregnant women should get a Tdap shot between weeks 27 and 36 of pregnancy. This is recommended for every pregnancy, regardless of when your last booster was.
People that will have close contact with a newborn may also need to get a Tdap shot at least 2 weeks before the baby is born. This might include a partner, grandparents, and other family members. But these people would only need a Tdap shot if its been more than 10 years since their last one.
Its important to note that these recommendations arent to protect against tetanus. Theyre to protect newborns against pertussis . As mentioned earlier, pertussis can be very dangerous to infants. Tdap shots are the only FDA-approved vaccines that protect against pertussis for people over 10.
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