What Are The Possible Side Effects Of Shingrix
Studies show that Shingrix is safe. The vaccine helps your body create a strong defense against shingles. As a result, you are likely to have temporary side effects from getting the shots. The side effects might affect your ability to do normal daily activities for 2 to 3 days.
Most people got a sore arm with mild or moderate pain after getting Shingrix, and some also had redness and swelling where they got the shot. Some people felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea. Some people who got Shingrix experienced side effects that prevented them from doing regular activities. Symptoms went away on their own in about 2 to 3 days. Side effects were more common in younger people.
You might have a reaction to the first or second dose of Shingrix, or both doses. If you experience side effects, you may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen.
Guillain-Barré syndrome , a serious nervous system disorder, has been reported very rarely after Shingrix. There is also a very small increased risk of GBS after having shingles.
If you experience side effects from Shingrix, you should report them to the Vaccine Adverse Event Reporting System . Your doctor might file this report, or you can do it yourself through the VAERS websiteexternal icon, or by calling 1-800-822-7967.
If you have any questions about side effects from Shingrix, talk with your doctor.
Who Should Not Get Shingrix
You should not get Shingrix if you:
- Have ever had a severe allergic reaction to any component of the vaccine or after a dose of Shingrix.
- Currently have shingles.
- Currently are pregnant. Women who are pregnant should wait to get Shingrix.
If you have a minor illness, such as a cold, you may get Shingrix. But if you have a moderate or severe illness, with or without fever, you should usually wait until you recover before getting the vaccine.
What Are The Risks Of The Shingrix Vaccine
Some people felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea. Some people who got Shingrix experienced side effects that prevented them from doing regular activities. Symptoms went away on their own in about 2 to 3 days. Side effects were more common in younger people.
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Who Should Not Get The Shingles Vaccine
Some people shouldnt get the shingles vaccine. These people include those:
- Who currently have shingles.
- Who have had a severe allergic reaction to the shingles vaccine in the past.
- Who have tested negative for immunity to the varicella-zoster virus, meaning youve never had chickenpox. If youve never had chickenpox, you should get the chickenpox vaccine.
- Who are ill. You should wait until your illness has passed before receiving the shingles vaccine.
- Who are pregnant or breastfeeding.
Vaccines And Multiple Sclerosis: A Practical Guide
Kathy Tortorice, PharmD, BCPS
Vaccines have been the focus of the news lately. Many questions come up when discussing the importance of vaccines for maintaining our health. Vaccines protect us from diseases without us having to experience the actual disease. Currently, there are vaccines available to protect children and adults against at least 17 serious diseases. Lets look at what vaccines are, who needs them, and some common questions or concerns people have about vaccines.
Vaccines are made using several different processes. They may contain live viruses that have been attenuated inactivated or killed organisms or viruses inactivated toxins , such vaccines are more stable and safer than live vaccines or merely segments of the pathogen .
It is important to be up to date on your vaccinations before starting a disease modifying therapy for your MS. Fingolimod might increase the risk of a potentially life-threatening varicella zoster so your provider will generally check for VZV antibodies before initiating fingolimod therapy. If immunity is not demonstrated by elevated VZV antibody levels, you will need the chicken pox vaccination before starting fingolimod. It is recommended that you then wait one month after your last VZV immunization to let the vaccine work before starting fingolimod therapy.
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Risks Of A Vaccine Reaction
- A sore arm with mild or moderate pain is very common after recombinant shingles vaccine. Redness and swelling can also happen at the site of the injection.
- Tiredness, muscle pain, headache, shivering, fever, stomach pain, and nausea are common after recombinant shingles vaccine.
These side effects may temporarily prevent a vaccinated person from doing regular activities. Symptoms usually go away on their own in 2 to 3 days. You should still get the second dose of recombinant shingles vaccine even if you had one of these reactions after the first dose.
Guillain-BarrÃ© syndrome , a serious nervous system disorder, has been reported very rarely after recombinant zoster vaccine.
People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears.
As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.
Shingles Disease And How To Protect Against It
Shingles, or herpes zoster, is a painful skin rash that develops on one side of the face or body. It is caused by the varicella-zoster virus , the same virus that causes chickenpox. Anyone who has had chickenpox in the past can get shingles because VZV remains in the body after a person recovers from chickenpox. VZV can reactivate many years later, causing shingles.
Shingles is more common in older adults, people who have medical conditions that weaken the immune system, and people who take medications that suppress their immune systems. Getting vaccinated is the best way to prevent shingles.
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Does Shingrix Require Two Shots
Shingrix is approved as a two-dose vaccine. It is not recommended to skip the second dose of Shingrix. Typically, the second Shingrix dose is administered two to six months after the first dose in adults aged 50 years and older. However, in people who are immunocompromised, the second dose can be given one to two months after the first dose.
How Is Shingrix Given
Shingrix is given as an injection into a muscle. A healthcare provider will give you this injection.
Shingrix is usually given in a series of 2 shots:
the second shot may be given any time within 2 to 6 months after the first shot.
for people who have a weak immune system, the second shot may be given any time within 1 to 2 months after the first shot.
You may receive this vaccine at the same time that you get a flu shot.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
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What Are The Side Effects
The shingles vaccines are very safe.
Common side effects to the vaccines include headache as well as soreness, redness and swelling where the vaccine was given. Itching and a rash may also occur after getting Zostavax® II. Other reactions that may occur after getting Shingrix® include fever, muscle soreness, fatigue, shivering, nausea, vomiting and diarrhea.
It is important to stay in the clinic for 15 minutes after getting any vaccine because there is an extremely rare possibility of anaphylaxis, which is a life-threatening allergic reaction. This may include hives, difficulty breathing, or swelling of the throat, tongue, or lips. The chance of true anaphylaxis is about 1 in 1 million vaccine doses. Should this reaction occur, your health care provider is prepared to treat it. Emergency treatment includes administration of epinephrine and transfer by ambulance to the nearest emergency department. If symptoms develop after you leave the clinic, call 9-1-1 or the local emergency number. Learn more about anaphylaxis on our vaccine side effects page.
It is important to always report serious or unexpected reactions to your health care provider.
Counseling Patients About Shingrix
Know the benefits and side effects of Shingrix so youre prepared to talk with your patients before administering the vaccine.
What to tell patients about Shingrix benefits:
- You can protect yourself against shingles. Shingles is a very painful disease, and your risk of getting it increases as you age. Also, you are more likely to have severe, long-term pain if you get shingles when you are older. About 1 out of every 3 people in the United States will develop shingles in their lifetime.
- Shingrix provides strong protection against shingles and long-term pain from the disease. Two doses of Shingrix are more than 90% effective at preventing shingles. So its very important that you get this vaccine.
What to tell patients about Shingrix side effects:
What to tell patients about dose two:
- You need to come back in 2 to 6 months for your second dose. We can make that appointment now.
- Even if you have side effects from the first dose, it is important to get the second dose to build strong protection against shingles. Your reaction to each dose may be different just because you have a reaction to the first dose does not mean that you will have a reaction to the second.
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Drug Interactions Of Shingrix Vs Zostavax
Immunosuppressive drugs, such as cyclosporine and tacrolimus, may decrease the effectiveness of vaccines. Steroids, like prednisone, and chemotherapy can also have immunosuppressive effects that can alter how well vaccines work.
People who are on immunosuppressive therapy should avoid Zostavax altogether Zostavax contains the live varicella-zoster virus, which could result in an infection. The risk of a vaccine-related infection may be increased if the bodys immune system is suppressed.
Antiviral drugs, such as acyclovir and famciclovir, may interfere with the effects of the Zostavax vaccine. The Advisory Committee on Immunization Practices recommends that people who are on antiviral drugs stop taking antiviral medications 24 hours before getting a Zostavax vaccine. Treatment with antiviral drugs should not be resumed for at least 14 days after vaccination with Zostavax. Clinical studies have found that getting both the Zostavax and Pneumovax vaccine at the same time may lead to a reduced immune response to Zostavax. The administration of Zostavax and Pneumovax should be separated by at least four weeks.
Consult a healthcare professional for other possible drug interactions
Administration With Other Vaccines
CDC general recommendations advise that recombinant and adjuvanted vaccines, such as Shingrix, can be administered concomitantly, at different anatomic sites, with other adult vaccines, including COVID-19 vaccines. Concomitant administration of Shingrix with Fluarix Quadrivalent , 23-valent pneumococcal polysaccharide vaccine and Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed , and 13-valent pneumococcal conjugate vaccine has been studied, and there was no evidence for interference in the immune response to either vaccine or safety concerns. Coadministration of Shingrix with adjuvanted influenza vaccine and COVID-19 vaccines is being studied.
Shingrix and pneumococcal vaccine can be administered at the same visit if the person is eligible for both. When both pneumococcal conjugate vaccine PCV13 and PPSV23 are recommended for an adult, PCV13 should always be administered first and can be administered concomitantly with Shingrix.
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How Effective Is The Shingrix Vaccine
The effectiveness of the Shingrix vaccine varies depending on the age of the person receiving the vaccine. Shingrix is 97 percent effective at preventing shingles in people between the ages of 50 and 69 who received both doses, while adults aged 70 and older reported 91 percent effectiveness in shingles prevention. Shingrix was able to prevent postherpetic neuralgia, a complication of shingles, in 91 percent of 50 to 69 year olds who received two doses of the vaccination and 89 percent of adults 70 and older who received the vaccine. It should be noted that the risk of shingles and its complications increases as a person ages, but people 70 and older still received a protection rate of 85 percent against the virus in the four years after vaccination.
Is Shingrix Or Zostavax More Effective
Shingrix and Zostavax have both been proven to prevent shingles. However, Shingrix is a newer vaccine that is considered more effective than Zostavax. Shingrix is even recommended for those who have already received the Zostavax vaccine in the past.
Clinical trials have shown that Shingrix is around 97% effective at preventing shingles in adults aged 50 to 69 years old. Shingrix is also effective in preventing shingles in older adultsin adults over the age of 70, Shingrix was found to be around 90% effective.
Zostavax has a 70% efficacy rate in preventing shingles in adults aged 50 to 69 years old, according to the Zoster Efficacy and Safety Trial . Results from the Shingles Prevention Study showed that, overall, Zostavax is 51% effective against shingles in adults older than 60 years old. However, the effectiveness of Zostavax . Zostavax is 64% effective in adults aged 60 to 69 years old, 41% effective in adults aged 70 to 79 years old, and 18% effective in adults aged 80 years and older.
Your healthcare provider will recommend Shingrix over Zostavax, as Shingrix is the preferred shingles vaccine and Zostavax is no longer available. Shingrix is especially recommended for immunocompromised patients since it is a non-live vaccine. Ask your doctor or pharmacist about the right shingles vaccine for you.
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Coverage And Cost Comparison Of Shingrix Vs Zostavax
For adults aged 50 years and older, only plans with Medicare Part D coverage will cover the Shingrix vaccine. However, there may still be a copay even with Medicare Part D coverage. The average cash price for one Shingrix dose is $167, though you may be able to use a prescription discount card to lower this cost. Check with your local pharmacy to see if you can use a Shingrix SingleCare card. Like Shingrix, Zostavax is primarily covered by Medicare Part D plans or Medicare Advantage plans with Medicare Part D coverage. The copay for Zostavax with insurance can vary. With an average cash price of $278, Zostavax can be expensive with or without insurance. Using a prescription discount card for Zostavax may be able to reduce this cost.
*not reportedFrequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.Source: DailyMed , DailyMed
Live Shingles Vaccine Vs Non
A live vaccine is one that contains a weakened form of a germ. Shingrix is not a live vaccine. Its an inactive vaccine, which is a vaccine thats made from a germ thats been killed.
Because Shingrix is inactive, more people can receive it. This includes people with a weakened immune system .
Zostavax was a shingles vaccine that was live.
People with weakened immune systems are typically advised against receiving live vaccines. This is because on very rare occasions, live vaccines can mutate back to the full-strength germ that causes a disease. If this happens, people with weakened immune systems would have a much higher risk for developing the disease that the vaccine is meant to prevent.
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Shingles Vaccine And Insurance
Private health insurance plans often cover vaccination costs. Still, a patient might have a charge depending on the specific insurance plan.
Medicaid may or may not cover the vaccine cost.Medicare Part D plans cover the shingles vaccine, but there may be a cost to the patient depending on the plan. Usually, the fees are less than $50 per dose.
Medicare Part B does not cover the shingles vaccine.
How Do I Get The Shingles Vaccination
Once you become eligible for the shingles vaccination, a GP or practice nurse will offer you the vaccine when you attend the surgery for general reasons.
You can have a shingles vaccine at the same time as most other vaccines. But try to leave 7 days between the shingles vaccine and a coronavirus vaccine, so that if you have any side effects you’ll know which vaccine they were from.
If you are worried that you may miss out on the shingles vaccination, contact your GP surgery to arrange an appointment to have the vaccine.
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Human Papilloma Virus Vaccine
COVID-19 vaccines are an important component to preventing the spread of the COVID-19 virus. COVID-19 causes very serious illness and death, particularly to vulnerable people including those who are older, immunocompromised, and have certain medical conditions. If you get COVID-19, you also risk giving it to loved ones who may get very sick. COVID-19 vaccines were tested in large clinical trials to make sure they met safety standards. It is not possible to get COVID-19 from getting the vaccination.
There are several types of COVID-19 vaccines. One type is called a messenger RNA vaccine . These vaccines instruct our cells to make a piece of the coronaviruss hallmark spike protein in order to spark an immune system response. Another vaccine type delivers the code of the spike protein directly to cells to spark the immune response . A third type is more like a traditional vaccine that delivers a piece of the actual virus spike protein to the body to spark the immune response . The upgrade with this type of vaccine is that it efficiently delivers an incredibly small piece of the virus . There is no chance that these vaccines change your DNA. Even after getting the vaccine you should continue to wear a mask around others, wash your hands, and practice physical distancing to prevent the virus from hopping from you to others even when you dont get sick. Additional guidance on COVID-19 vaccines can be found on the MSCoE COVID-19 and Vaccine webpage.