How Do Inactivated Viral Vaccines Work
Inactivated viralvaccines are sterile biologic products that provide immunity against viral infections. Inactivated viral vaccines work by stimulating the bodys immune system to produce antibodies against specific types of viruses, and protect a person from becoming infected when exposed to these viruses.
In the case of SARS-CoV-2 coronavirus that causes respiratory illness and has led to the COVID-19 pandemic, vaccines do not entirely prevent infection but protect vaccinated individuals from serious illness and hospitalization from the disease.
Inactivated viral vaccines contain particles of proteins or genetic material from viruses. Inactivated viral vaccines may also contain substances that preserve and stabilize the vaccine, and enhance immune response. Some viral vaccines are delivered in inactivated harmless viruses such as human adenovirus.
Inactivated viral vaccines may be made from:
- Surface proteins of the viruses enable the virus to hold on to a human cell, enter inside and replicate.
- Modified RNA particles from the virus can enter host cells and induce the production of viral antigen, which stimulates an immune response from the body.
- Recombined DNA material from multiple strains and subtypes of viruses, killed to eliminate disease-causing capability.
Currently, inactivated viral vaccines approved by the FDA protect against viral infectious diseases that include:
- Coronavirus disease , caused by SARS-Cov-2 virus
Adults
Very Common And Common Adverse Events
Very common adverse events occur in 10% or more of vaccinees. Common adverse events occur in 1% to less than 10% of vaccinees.
Injection site reactions are very commonly reported for both LZV and RZV. For LZV recipients the frequency is slightly higher in adults aged < 60 years. For all ages, the majority of these events were rated mild or moderate in intensity and lasted less than 2 days.
Due to the adjuvant in RZV, which induces a high cellular immune response and helps address the natural age-related decline in immunity, RZV is more reactogenic than LZV.
Injection site AEs are very commonly reported by recipients of RZV. Approximately 80% report injection-site pain and approximately 30% report redness at the site of injection.
Systemic adverse events, primarily fatigue and myalgia are common in LZV recipients and very common in RZV recipients . For RZV, they include headache .
Local and systemic reactions that were severe enough to interfere with normal activities have been more frequently reported following the receipt of RZV than LZV. However, these reactions have been temporary . Patient education on the short-term reactogenicity of the RZV is recommended prior to vaccine administration to promote adherence to the second dose.
What Are The Possible Side Effects Of Shingrix
Studies show that Shingrix is safe. The vaccine helps your body create a strong defense against shingles. As a result, you are likely to have temporary side effects from getting the shots. The side effects may affect your ability to do normal daily activities for 2 to 3 days.
Most people got a sore arm with mild or moderate pain after getting Shingrix, and some also had redness and swelling where they got the shot. Some people felt tired, had muscle pain, a headache, shivering, fever, stomach pain, or nausea. About 1 out of 6 people who got Shingrix experienced side effects that prevented them from doing regular activities. Symptoms went away on their own in about 2 to 3 days. Side effects were more common in younger people.
You might have a reaction to the first or second dose of Shingrix, or both doses. If you experience side effects, you may choose to take over-the-counter pain medicine such as ibuprofen or acetaminophen.
If you experience side effects from Shingrix, you should report them to the Vaccine Adverse Event Reporting System . Your doctor might file this report, or you can do it yourself through the VAERS websiteexternal icon, or by calling 1-800-822-7967.
If you have any questions about side effects from Shingrix, talk with your doctor.
The shingles vaccine does not contain thimerosal .
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New Shingles Vaccine: What You Need To Know
Nov. 13, 2019 — Unlike some vaccines, thereâs been so much demand for the new shingles vaccineShingrix that itâs not always easy to find. It was approved in 2017, and the CDC recommends the vaccine for adults 50 and older to prevent this painful, blistering illness. It is being used in place of the previous vaccine, Zostavax.
More than a year later, doctors say they are learning more about how it works, its safety risks, and how it compares to Zostavax.
How effective is Shingrix?
âIt’s just remarkable,” says Wilbur Chen, MD, an associate professor of medicine at the Center for Vaccine Development and Global Health, University of Maryland School of Medicine. “It has performed better than I expected.”
In studies, Shingrix was more than 97% effective at preventing shingles in people 50 and older. It works just as well in older adults, who are at greater risk for a painful shingles complication called postherpetic neuralgia . “When 70- and 80-year-olds get shingles, it can be extremely debilitating,” Chen says.
By contrast, Zostavax cuts the risk of shingles by only 51% and PHN by 67%. It’s only about 38% effective in people over age 70.
How safe is Shingrix?
“So far so good,” Schaffner says. The main side effect is soreness in the arm where you get the shot.
Other side effects are mild and usually last for 2 to 3 days, including:
- Redness
- Stomach pain
- Nausea
Who shouldn’t get Shingrix?
Can I get the Shingrix vaccine now?
How do I pay for Shingrix?
Schedule : Pharmacy Medicine

Schedule 2 drugs and poisons, otherwise known as Pharmacy Medicines, are substances and preparations for therapeutic use that
- are substantially safe in use but where advice or counselling is available if necessary
- are for minor ailments or symptoms that
- can be easily recognised by the consumer and
- do not require medical diagnosis or management.
Examples:
- , a cough suppressant
- Simple analgesics such as , and in packs containing more than 24 tablets
- , used to treat motion sickness, postoperative nausea and vomiting.
- containing or
The SUSMP March 2018 defines a Schedule 2 substance as “Substances, the safe use of which may require advice from a pharmacist and which should be available from a pharmacy or, where a pharmacy service is not available, from a licensed person.”
The location of these medications in the pharmacy varies from state to state.
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Coverage And Cost Comparison Of Shingrix Vs Zostavax
For adults aged 50 years and older, only plans with Medicare Part D coverage will cover the Shingrix vaccine. However, there may still be a copay even with Medicare Part D coverage. The average cash price for one Shingrix dose is $167, though you may be able to use a prescription discount card to lower this cost. Check with your local pharmacy to see if you can use a Shingrix SingleCare card.
Like Shingrix, Zostavax is primarily covered by Medicare Part D plans or Medicare Advantage plans with Medicare Part D coverage. The copay for Zostavax with insurance can vary. With an average cash price of $278, Zostavax can be expensive with or without insurance. Using a prescription discount card for Zostavax may be able to reduce this cost.
* |
*not reportedFrequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.Source: DailyMed , DailyMed
How Does The Shingles Vaccine Work
The vaccine recommended for most people is a live vaccine called Zostavax. It contains a weakened chickenpox virus . It’s similar , but not identical, to the chickenpox vaccine.
People with a weakened immune system cannot have live vaccines. They will be offered a non-live vaccine called Shingrix. It activates the immune system but also contains an ingredient called an adjuvant, which helps to boost the response to the vaccine.
Very occasionally, people develop chickenpox following shingles vaccination . Talk to a GP if this happens to you.
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Cdc Recommendation For The Shingles Vaccine
The Centers for Disease Control and Prevention recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease.
The CDC found that Shingrix was more effective than Zostavax. It recommends that you receive Shingrix, even if youve had Zostavax in the past.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.
Considerations For Patients Who Previously Received Zostavax
Studies have not examined the safety and immunogenicity of Shingrix administered less than 5 years following Zostavax® vaccination. However, there are no data or theoretical concerns to indicate that Shingrix would be less safe or less effective when given at an interval shorter than 5 years following Zostavax. Since the risk of herpes zoster increases with age, providers should weigh a patients risk of herpes zoster with the age-specific protection expected from Zostavax to determine when to vaccinate with Shingrix.
- Shingles=Herpes Zoster or Zoster
- VZV=varicella zoster virus
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Shingrix Shingles Vaccine Description
GSK’s Shingrix is a non-live, adjuvanted recombinant shingles vaccine , consisting of the varicella-zoster virus glycoprotein E antigen and the AS01B adjuvant system, a proprietary adjuvant containing QS-21 and MPL with liposomes.
Shingrix has been up to 90% effective in various clinical trials, says GSK. Shingles, also known as herpes zoster, is a painful skin rash caused by reactivation of the varicella-zoster virus, which causes chickenpox, says the U.S. CDC. In addition, Shingrix works to boost immune systems as people age, which increases the risk for shingles.
Recombinant zoster vaccine has been used since 2017, says the U.S. CDC. On October 20, 2017, the U.S. FDA issued its authorization: STN: 125614. The EMA issued EMEA/H/C/004336 on March 21, 2018.
The American Academy of Dermatology Journal reported that among people who had a first-time shingles attack, approximately 4% had another outbreak later. In addition, those ages 45 to 54 had a recurrence after two years on average, while people ages 55 and older had one three years later on average. Given the recurrence rates, the researchers said that people who’d already had shingles would still benefit from getting the vaccine, stated Harvard Health. Furthermore, a separate study reported two cases of de novo disseminated varicella-zoster virus infection, without expansion from an initial dermatomal presentation, after receiving an mRNA-based COVID-19 vaccine in patients who were not actively on immunosuppression.
How Safe Is Shingrix
studies showed that Shingrix was safe and effective.
There have been concerns about ingredients, such as thimerosal, that may be added to vaccines. Thimerosal is a kind of preservative that contains mercury. Its added then taken out of some vaccines to keep other germs and bacteria from growing. The concern arose when early research connected thimerosal to autism. This link has since been found to be false. Shingrix doesnt contain thimerosal.
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Who Should Not Get Shingrix
You should not get Shingrix if you:
- have ever had a severe allergic reaction to any component of the vaccine or after a dose of Shingrix
- tested negative for immunity to varicella zoster virus. If you test negative, you should get chickenpox vaccine.
- currently have shingles
- currently are pregnant or breastfeeding. Women who are pregnant or breastfeeding should wait to get Shingrix.
If you have a minor acute illness, such as a cold, you may get Shingrix. But if you have a moderate or severe acute illness, you should usually wait until you recover before getting the vaccine. This includes anyone with a temperature of 101.3°F or higher.
The side effects of the Shingrix are temporary, and usually last 2 to 3 days. While you may experience pain for a few days after getting Shingrix, the pain will be less severe than having shingles and the complications from the disease.
What Can I Expect After Getting The Vaccine

Shingrix is a two-part vaccine with the second dose given 2-6 months after the first. If you miss this timeframe, then you do not have to repeat the series. The vaccine is given into the muscle, much like an influenza, pneumonia or tetanus vaccine.
Once you get the vaccine, you are more likely to experience fatigue, achy muscles, fever, shivering or upset stomach compared to the older vaccine. Approximately 11 percent of people who get the vaccine reported these flu-like symptoms and another nine percent reported mild pain, redness, and swelling at the site of the injection. These symptoms are more likely to occur after the second dose and typically resolve in a few days.
Shingrix represents a real opportunity to protect ourselves against a debilitating disease with remarkable and long-lasting effectiveness. Speak with your Methodist Physicians Clinic primary care provider about being vaccinated.
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How Well Does Shingrix Work
Two doses of Shingrix provides strong protection against shingles and postherpetic neuralgia , the most common complication of shingles.
- In adults 50 to 69 years old who got two doses, Shingrix was 97% effective in preventing shingles among adults 70 years and older, Shingrix was 91% effective.
- In adults 50 to 69 years old who got two doses, Shingrix was 91% effective in preventing PHN among adults 70 years and older, Shingrix was 89% effective.
Shingrix protection remained high in people 70 years and older throughout the four years following vaccination. Since your risk of shingles and PHN increases as you get older, it is important to have strong protection against shingles in your older years.
Shingrix Vaccine Efficacy And Duration Of Protection
The efficacy of two doses of Shingrix for the prevention of herpes zoster was high among all age groups. In a clinical trial of more than 30,000 participants, vaccine efficacy was 96.6% in adults age 50 to 59 years, 97.4% in adults age 60 to 69 years, and 91.3% in adults age 70 years and older. Vaccine efficacy remained high in adults age 70 years and older, at or above 84.7% in all four years after vaccination.
The efficacy of two doses of Shingrix for the prevention of postherpetic neuralgia was high: 91.2% in adults age 50 years and older, and 88.8% in adults age 70 years and older.
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Im Living With Hiv Is It Safe For Me To Get Shingrix
The Centers for Disease Control and Prevention hasnt made a recommendation about the use of Shingrix in people living with HIV.
However, one study looked at healthy adults ages 18 and older who were living with HIV and had an HIV dosing schedule that was customized to their needs. These people received the Shingrix vaccine, and the study results did not report any safety issues.
If youre living with HIV, talk with your doctor about the risks and benefits of getting Shingrix.
How Is Shingrix Given
Shingrix is given as an injection into a muscle. A healthcare provider will give you this injection.
Shingrix is usually given in a series of 2 shots. The second shot may be given any time within 2 to 6 months after the first shot.
You may receive Shingrix at the same time that you get a flu shot.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
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Shingrix Shingles Vaccine Use For Immunocompromised Adults
During the U.S. CDC’s Advisory Committee on Immunization Practices meeting on October 20, 2021, Tara Anderson, DVM, MPH, Ph.D., presented: Interpretation of the EtR Regarding Use of RZV in Immunocompromised Adults, Considerations for Use, and Proposed Policy Options. The ACIP’s Recommendation is: Two doses of recombinant zoster vaccine are recommended for adults aged 19 years who are or will be immunodeficient or immunosuppressed due to disease or therapy to prevent herpes zoster and its complications. Additionally, Camille Nelson Kotton, M.D., presented an ACIP herpes zoster overview.
Previously, Camille Nelson Kotton, M.D., Chair, ACIP Herpes Zoster Work Group, presented the Introduction Zoster Vaccines Session on September 29, 2021 Ismael R. Ortega-Sanchez, Ph.D. presented ‘Economics of vaccinating immunocompromised 1949-years-old adults against herpes zoster in the USA Tara Anderson, DVM, MPH, Ph.D. presented ‘Preliminary Evidence to Recommendations Framework Regarding Use of Recombinant Zoster Vaccine in Immunocompromised Adults and Next Steps.’
How To Use Shingrix Kit
Read all vaccine information available from your health care professional before receiving the vaccine. If you have any questions, ask your health care professional.
This vaccineis given by injection into a muscle by a health care professional. It is usually given in the upper arm.
This vaccine is usually given in a series of 2 doses to provide the best protection. Closely follow the vaccination schedule provided by the health care professional. Keep all scheduled medical appointments. It may be helpful to mark a calendar as a reminder.
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Shingrix Shingles Vaccine Dosage
Shingrix is a suspension for intramuscular injection only. It is supplied in 2 vials that must be combined before administration. Two doses are necessary to provide strong protection, up to 90%, the first dose at Month 0, followed by a second dose administered anytime between 2 and 6 months. The Shingrix vaccine series is administered as an injection into the upper arm’s muscle. Therefore, it is important to complete the 2dose series to help prevent shingles. The CDC has stated: If more than six months have elapsed since the 1st Shingrix dose, administer the 2nd dose as soon as possible. Do not restart the Shingrix vaccine series.