When Do You Get The Gardasil Vaccine

What Do The Vaccines Protect Against

Gardasil® provides protection against four HPV types: two that cause approximately 70 per cent of all cervical cancers and two that cause approximately 90 per cent of all anogenital warts in males and females . Gardasil®9 prevents up to an additional 14% of anogenital cancers caused by the additional five HPV types included in the vaccine.

Cervarix® provides protection against the two HPV types that cause approximately 70 per cent of all cervical cancers .

The HPV vaccines will not have an impact on an existing infection or any of the outcomes of an existing HPV infection, such as anogenital warts. The vaccines are preventative against infection with the virus types for which they are indicated. There is currently no vaccine that will give protection against all HPV types.

Gardasil 9 Vaccine Side Effects

Get emergency medical help if you have signs of an allergic reaction to Gardasil 9:hives difficulty breathing swelling of your face, lips, tongue, or throat.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

You may feel faint after receiving this vaccine. Some people have had seizure like reactions after receiving this vaccine. Your doctor may want you to remain under observation during the first 15 minutes after the injection.

Developing cancer from HPV is much more dangerous to your health than receiving the vaccine to protect against it. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Common Gardasil 9 side effects may include:

• pain, swelling, redness, itching, bruising, bleeding, and a lump where the shot was given

• nausea, diarrhea, stomach pain

Common Questions About The Hpv Vaccine Schedule

ACIP makes recommendations based on the best available scientific evidence. Immunogenicity studies show that two doses of HPV vaccine given at least 6 months apart to 914-year-olds provided as good or better antibody responses as three doses given to older adolescents or young adults.

Answering parents questions: The data we have from current scientific studies show that in children age 914 years, two doses of HPV vaccine given at least 6 months apart were as good or better as three doses. The immune response for older people hasnt been studied in the same way, so information is not available for that age group. For this reason, older teens and adults should get three doses for best protection.

Yes. In a 2-dose schedule of HPV vaccine, the recommended interval is 612 months, and the minimum interval is 5 months between the first and second dose. If the second dose is given earlier than 5 months, a third dose should be given.

Answering parents questions: The recommended schedule is two doses given 6 12 months apart. The minimum amount of time between those doses is 5 months. Because your child received two doses less than 5 months apart, your child should get a third dose.

Answering parents questions: Since your child received the first dose before 15 years of age, they only need one more dose to be fully protected. However, the second dose should be given as soon as possible and not further delayed.

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A New Study Suggests That One Dose Of The Hpv Vaccine Instead Of The Recommended Two Or More Might Offer Enough Protection What Do You Make Of That

Dr. Kriplani: I think this is very promising early data. It sets the stage for additional studies. We would need long-term follow-up data before recommending a single-dose regimen.

Dr. Aragones: The guidelines are very clear that two or three doses of the HPV vaccine are needed for full protection. There is some initial evidence that one dose may be enough, but were not there yet. Its important to note that the reason for going down to one dose is not for safety or effectiveness. Were looking to see if it offers enough protection if it does, it would be easier to immunize a lot of people worldwide.

Are There Hpv Vaccine Side Effects

Research shows that the vaccine is safe. The most common side effect is temporary pain and redness where you get the shot.

One of the reasons the HPV vaccine is controversial is because it prevents a sexually transmitted infection, which leads some people to believe its inappropriate for children. But, the thing is, the vaccine works best if you get it long before you have sex. So its a good idea to get it when youre young so you wont have to worry about getting certain kinds of cancer later in life.

Studies show that the HPV vaccine doesnt lead to people having more sex or sex at a younger age. So giving kids the HPV vaccine doesnt encourage them to have sex. All it does is help protect them from genital warts and cancer in adulthood.

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Would Someone Know If They Had Hpv

Dr. Kriplani: The only people who can know for sure are females, who can have their cervixes tested. For males, theres no way of knowing unless you develop an HPV-associated cancer or benign condition like a wart. Thats one reason were seeing more and more head and neck cancers in men in their 50s and sometimes even 40s because theres no test to tell whether theyve been infected.

Dose And Route Of Administration

Dose

Pfizer-BioNTech Comirnaty COVID-19 vaccine

There are two formulations of Comirnaty authorized for use in individuals 12 years of age and older.

• Vials with a purple cap and a purple label border: DILUTE with 1.8 mL 0.9% Sodium Chloride Injection, USP prior to use.
• Each dose is 0.3 mL after dilution, containing 30 mcg of SARS-CoV-2 spike protein mRNA.

The dose for the Pfizer-BioNTech Comirnaty COVID-19 vaccine is unique compared to that of most routine vaccinations. Special precaution should be taken to ensure the correct dose is taken from the multi-dose vial.

Pfizer-BioNTech Comirnaty COVID-19 vaccine

This formulation has an orange vial cap and orange label border and is authorized for use in those 5 to 11 years of age.

Dilute with 1.3 mL 0.9% Sodium Chloride Injection, USP prior to use.

Each dose is 0.2 mL after dilution, containing 10 mcg of SARS-CoV-2 spike protein mRNA.

The dose for the Pfizer-BioNTech Comirnaty COVID-19 vaccine pediatric formulation is unique compared to that of most routine vaccinations. Special precaution should be taken to ensure the correct dose is taken from the multi-dose vial.

Moderna Spikevax COVID-19 vaccine

For use in individuals 6 to 11 years of age:

Each dose is 0.25 mL, containing 50 mcg of SARS-CoV-2 spike protein mRNA.

For use in individuals 12 years of age and older:

For booster doses:

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Can A Vaccine Help Prevent Hpv

Yes. Vaccines are available to help prevent infection by certain types of HPV and some of the cancers linked to those types. As of 2020, Gardasil 9 is the only HPV vaccine available in the United States. Other HPV vaccines are available outside the U.S.

All of these vaccines help prevent infection by HPV-16 and HPV-18. These 2 types cause most cervical cancers and pre-cancers, as well as many cancers of the anus, penis, vulva, vagina, and throat.

Gardasil 9 helps prevent infection by 4 types of HPV , plus 5 other high risk types: 31, 33, 45, 52 and 58. Together these types cause about 90% of cervical cancers.

Who Should Get Hpv Vaccination

The Centers for Disease Control and Preventions Advisory Committee on Immunization Practices develops recommendations regarding all vaccination in the United States, including HPV vaccination. The current ACIP recommendations for HPV vaccination are :

• Children and adults ages 9 through 26 years. HPV vaccination is routinely recommended at age 11 or 12 years vaccination can be started at age 9 years. HPV vaccination is recommended for all persons through age 26 years who were not adequately vaccinated earlier.
• Adults ages 27 through 45 years. Although the HPV vaccine is Food and Drug Administration approved to be given through age 45 years, HPV vaccination is not recommended for all adults ages 27 through 45 years. Instead, ACIP recommends that clinicians consider discussing with their patients in this age group who were not adequately vaccinated earlier whether HPV vaccination is right for them. HPV vaccination in this age range provides less benefit because more people have already been exposed to the virus.
• Persons who are pregnant. HPV vaccination should be delayed until after pregnancy, but pregnancy testing is not required before vaccination. There is no evidence that vaccination will affect a pregnancy or harm a fetus.

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Children In Licensed Daycare Centres

If you want your child to attend daycare, and decide not to vaccinate them due to medical, religious or philosophical reasons, you will need to give your daycare a valid written exemption. If the disease appears in your childs daycare centre, your child may have to stay out of daycare until the disease is no longer present.

How Effective Are The Vaccines

The HPV vaccines have demonstrated very high efficacy in preventing the types of HPV infection for which they are indicated . If you are infected with one of the HPV types in the vaccine, the vaccine will still protect against the other type in the vaccine. HPV DNA testing is not recommended prior to vaccination.

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How Do I Obtain The Vaccine Do I Need To Pay For The Vaccine

The provision of free medications, vaccines and health services is a decision that is made within each province and territory. Please check with your provincial/territorial public health department. If you or your child is not eligible for HPV vaccination under an immunization program, you can speak with your healthcare provider if you wish to purchase the vaccine.

When Should You Be Vaccinated

The vaccines are given 2 or 3 times over a 6- to 12-month period. The timing of doses is important to make sure the vaccines are as effective as possible. If all doses of the vaccine are not given, or they are not given at the right time, you may not get the full benefit of the vaccine.

The vaccines are most effective if theyre given before a person becomes sexually active because their risk of infection will be lower. The vaccines are also more effective in young teens when the immune system is most responsive to the vaccine.

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Tuberculin Skin Testing Or Interferon Gamma Release Assay

There is a theoretical risk that mRNA or viral vector vaccines may temporarily affect cell-mediated immunity, resulting in false-negative TST or IGRA test results. If tuberculin skin testing or an IGRA test is required, it should be administered and read before immunization or delayed for at least 4 weeks after vaccination. Vaccination with COVID-19 vaccines may take place at any time after all steps of tuberculin skin testing have been completed.

In cases where an opportunity to perform the TST or IGRA test might be missed, the testing should not be delayed since these are theoretical considerations. However, re-testing of individuals with negative results for whom there is high suspicion of tuberculosis infection may be prudent in order to avoid missing cases due to potentially false-negative results.

Can’t I Avoid Cervical Cancer By Simply Getting Routine Pap Testing

No. At one time cervical cancer was the most common cause of cancer in the United States. One test changed that: the Papanicolaou test. The Pap test is performed by scraping cells from the opening of the cervix and examining them under the microscope to see whether they have begun to show changes consistent with the early development of cancer . Typically, the length of time from infection with HPV to development of cervical cancer is about 15-20 years. For this reason, although most HPV infections occur in teenagers and young adults, cervical cancer is more common in women in their 40s and 50s.

The Pap test is one of the most effective cancer screening tests available and has dramatically reduced the incidence of cervical cancer in the United States. But the test isn’t perfect and not all women get tested as often as they should.

On the flip side, even if you have been vaccinated against HPV, you are still recommended to get the Pap test.

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Who Should Not Be Vaccinated

Anyone who has ever had a life-threatening allergic reaction to any component of HPV vaccine, or to a previous dose of HPV vaccine, should not get the vaccine. Tell your doctor about any severe allergies, including an allergy to latex or yeast.

HPV vaccine is not recommended for pregnant women. Women who are breastfeeding may get the vaccine.

People who are mildly ill when a dose of HPV vaccine is planned can still be vaccinated.

Why You Should Vaccinate

Infectious diseases can spread among children and adolescents at school who are not vaccinated. As a parent, you can keep your kids healthy with routine health care and vaccines. Make sure your school-age children are up-to-date with their vaccinations.

Infection from certain diseases can kill or seriously harm your child. Vaccines use weakened or killed virus or bacteria to trigger your childs natural immune response to provide long-term protection against a disease . It is like a rehearsal for the immune system, so your child is prepared if they are exposed to the “real” disease.

Vaccinations are safe

Vaccinations do not cause autism.

Scientific studies and reviews continue to show no relationship between vaccines and autism.

Some people wont develop immunity to a disease after being vaccinated, but the vaccine itself cannot infect someone. If a vaccinated individual does contract a disease which they were vaccinated against, their illness will be less severe.

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Who Should Get The Hpv Vaccine

All people ages 9 to 45 can get the HPV vaccine to protect against genital warts and/or different types of HPV that can cause cancer. Its recommended that children get the vaccine at age 11 or 12, so theyre fully protected years before they become sexually active.

But regardless of your age, talk with your nurse or doctor to find out if the HPV vaccine could benefit you.

Hpv Vaccine Schedule And Dosing

About 85% of people will get an HPV infection in their lifetime. Vaccinating all 1112-year-olds can protect them long before they are ever exposed.

CDC recommends two doses of HPV vaccine for all adolescents at age 11 or 12 years.

• A 2-dose schedule is recommended for people who get the first dose before their 15th birthday. In a 2-dose series, the second dose should be given 612 months after the first dose .
• The minimum interval is 5 months between the first and second dose. If the second dose is administered after a shorter interval, a third dose should be administered a minimum of 5 months after the first dose and a minimum of 12 weeks after the second dose.
• If the vaccination schedule is interrupted, vaccine doses do not need to be repeated .
• Immunogenicity studies have shown that two doses of HPV vaccine given to 914-year-olds at least 6 months apart provided as good or better protection than three doses given to older adolescents or young adults.

A 3-dose schedule is recommended for people who get the first dose on or after their 15th birthday, and for people with certain immunocompromising conditions.

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Hpv Vaccine Safety Concerns

HPV vaccine and autoimmune diseases

Bi D, Apter D, Eriksson T, Hokkanen M, Zima J, et al. Safety of the AS04-adjuvanted human papillomavirus -16/18 vaccine in adolescents aged 12-15 years: end-of-study results from a community-randomized study up to 6.5 years. Human Vaccines and Immunotherapy 2019 12:1-12 .In this randomized study, the authors evaluated the efficacy and safety of an adjuvanted-HPV 16/18 vaccine in more than 32,000 Finnish adolescent males and females over a 6.5-year period by comparing those who received HPV vaccine to those who received hepatitis B vaccine. The HPV vaccine adjuvant was composed of monophosphoryl-lipid A plus aluminum salts. The incidence of new-onset autoimmune diseases was similar in both vaccine groups. Similarly, those receiving HPV vaccine during pregnancy did not have an increased risk for spontaneous abortion or congenital anomalies.

Grimaldi-Bensouda L, Rossignol M, Kone-Paut I, et al. Risk of autoimmune diseases and human papilloma virus vaccines: six years of case-referent surveillance. Journal of Autoimmunity 2017 19:84-90.The authors found that HPV vaccine did not increase the risk of autoimmune diseases in females 11 to 25 years of age. Autoimmune diseases included central demyelination, multiple sclerosis, connective tissue disease, Guillain-Barré syndrome, type 1 diabetes, autoimmune thyroiditis, and idiopathic thrombocytopenic purpura.

HPV and chronic fatigue syndrome /systemic exertion intolerance disease

Are There Different Types Of Hpv Vaccines

HPV is a group of more than 200 viruses. About 40 of these are spread through sexual contact. Of these 40, about 12 types can cause certain cancers. There are three safe and effective HPV vaccines available worldwide:

• Gardasil® 9: This is the only vaccine currently being used in the United States. Gardasil 9 protects against nine types of cancer-causing HPV, including high-risk strains. It can prevent up to 90% of cervical cancers.
• Cervarix® and Gardasil®: These two HPV vaccines are used in other countries and treat certain high-risk strains of HPV. They can prevent around 70% of cervical cancer.

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