How Long Does Shingrix Last
The immunity conferred from Shingrix for the prevention of shingles is thought to last longer, and be more effective than the previous shingles vaccine, Zostavax.
The immune response from the shingles vaccine Shingrix is reported to be at least nine years based on the cellular response to the vaccine according to the CDC. However, âimmune responseâ doesnât necessarily correlate to vaccine effectiveness in terms of preventing episodes of shingles.
Other data indicates that the Shingrix vaccine maintains greater than 90% efficacy at least four years after vaccination according to GlaxoSmithKline, the manufacturer of the vaccine.
In addition, the New England Journal of Medicine has reported that Shingrix maintains around 88% efficacy at least four years after vaccination in patients vaccinated 70 years of age or older.
Mild Side Effects Of Shingles Vaccine:
- Redness, soreness, swelling, or itching at the site of the injection .
It is safe to be around infants and young children, pregnant women, or people with weakened immune systems after you get the shingles vaccine. There is no documentation of a person getting chickenpox from someone who has received the shingles vaccine .
Some people who get the shingles vaccine will develop a chickenpox-like rash near the place where they were vaccinated. As a precaution, this rash should be covered until it disappears.
Like all vaccines, shingles vaccine is being closely monitored for unusual or severe problems by CDC and FDA.
Signs of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. These would start a few minutes to a few hours after the vaccination. If you have a severe allergic reaction or other emergency that cant wait, call 9-1-1 or get the person to the nearest hospital. Otherwise, call your doctor.
Afterward, the reaction should be reported to the Vaccine Adverse Event Reporting System . Your doctor might file this report, or you can do it yourself through the VAERS website, or by calling 1-800-822-7967.
The shingles vaccine does not contain thimerosal .
This information was taken directly from the Shingles Vaccine Information Statement dated 10/06/2009.
For more information on possible side effects from vaccination, visit CDCs Possible Side Effects from Vaccines page.
Shingles On Your Buttocks
You can get a shingles rash on your buttocks. Shingles usually only affects one side of your body, so you may have a rash on one buttock but not the other.
As with other areas of the body, shingles on your buttocks may cause initial symptoms like tingling, itching, or pain.
After a few days, a red rash or blisters may develop. Some people experience pain but dont develop a rash.
. After the varicella-zoster virus initially reactivates, your skin may:
Shingles usually develops on one side of your body, often on your waist, back, or chest.
Within about 5 days, you may see a red rash in that area. Small groups of oozing, fluid-filled blisters may appear a few days later in the same area. You may experience flu-like symptoms such as a fever, headache, or fatigue.
During the next 10 days or so, the blisters will dry up and form scabs. The scabs will clear after a couple of weeks. After the scabs clear, some people continue to experience pain. This is called postherpetic neuralgia.
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What Questions Should I Ask My Healthcare Provider
Its normal to have questions before you get a vaccine. Some common questions you may want to discuss with your healthcare provider include:
- When should I get the shingles vaccine?
- What side effects should I expect?
- How does the shingles vaccine work?
- When should I schedule each dose of the shingles vaccine?
- How effective is the shingles vaccine?
- Is there any reason I shouldnt get the shingles vaccine?
- What could happen if I dont get the shingles vaccine?
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More Common Side Effects
The more common side effects of Shingrix can include:
- pain, redness, and swelling at site of injection*
- dizziness or fainting
- flu-like symptoms, including fever, shivering, and tiredness
Most of these side effects may go away within a few days or a couple of weeks. If theyre more severe or dont go away, talk to your doctor or pharmacist.
* For more information about this side effect, see Side effect details below.
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Shingrix For Prevention Of Shingles
Shingrix is a vaccine thats used to prevent shingles . Its approved for use in people:
- ages 50 years and older
- ages 18 years and older who have an increased risk of shingles
People with an increased risk of shingles include those with a weakened immune system, such as people with HIV.
Shingrix is not meant for use in preventing chickenpox .
Effectiveness for prevention of shingles
Shingrix has been found to be effective in helping to prevent shingles. For details on how the drug performed in clinical studies, see Shingrixs
state that Shingrix is the preferred vaccine for shingles. They recommend it for:
- all adults ages 50 years and older
- adults ages 18 to 50 years with a weakened immune system
Shingrix And Other Medications
Below are medications that can interact with Shingrix. These are not all the drugs that may interact with Shingrix.
Before taking Shingrix, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Immunosuppressive drugs such as prednisone
Taking Shingrix with drugs that suppress your immune system can cause problems with the way your body responds to Shingrix. Examples of immunosuppressive medications include:
- corticosteroids, such as:
Here are answers to some frequently asked questions about Shingrix.
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Cost And Formulary Considerations
Herpes zoster is associated with significant economic and public health costs in the U.S.14 A 2016 cost analysis estimated the annual direct and indirect costs related to herpes zoster as $782 million.15 In addition, the projected cost of herpes zoster in people 65 years and older will be $4.74 billion by 2030.14Table 4 includes a cost comparison between HZ/su and ZVL. The average wholesale price of each Hz/su dose is $173, with a total cost of $346.13 Unlike influenza and pneumococcal vaccines, which are covered by Medicare Part B, herpes zoster vaccines are covered under Medicare Part D, which may present an economic challenge for many Medicare recipients.14
Guidance On Reporting Adverse Events Following Immunization
Vaccine providers are asked to report AEFIs through local public health officials and to follow AEFI reporting requirements that are specific to their province or territory. In general, any serious or unexpected adverse event felt to be temporally related to vaccination should be reported.
For LZV the following AEFIs are also of particular interest and should be reported:
- Suspected transmission of vaccine-strain virus to a close household or occupational contact. This phenomenon has been documented following varicella vaccine but it is rare, and transmission has not been documented with LZV.
- Recurrent HZ following immunization of individuals with a history of HZ prior to immunization, noting the area of recurrence.
- Recurrent HZO following immunization of a person who has had a previous episode of HZO. If available, a vitreous fluid specimen should be sent to a laboratory with a request to determine whether the virus is the vaccine strain or wild type virus.
For definitions of serious and unexpected adverse events, refer to Adverse Events Following Immunization in Part 2.
For more information refer to Reporting Adverse Events Following Immunization in Canada.
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Should You Get Shingrix If You Had The Zostavax Shingles Vaccine
It is recommended that you get two doses of Shingrix even if you got a different shingles vaccine in the past. Before Shingrix was approved, the Zostavax shingles vaccine was available. It was discontinued in November 2020 as Shingrix is much more effective. If you had the Zostavax vaccine, talk to your healthcare provider about getting Shingrix.
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How Long Shingles Lasts And How Serious It Can Be
The rash usually appears a few days after the initial pain and tingling, and lasts for about a week. The older you are, the more likely you are to have long-lasting pain. Sometimes shingles develops in the eye and may also affect the eyelid.
This can cause severe pain and lead to decreased vision or even permanent blindness in that eye. Most people recover fully, but for some, the pain goes on for several months or even years this is called post-herpetic neuralgia .
This is a particularly unpleasant condition with severe burning, throbbing or stabbing nerve pain. The vaccine reduces the risk of getting shingles and PHN. Even if you still get shingles, the symptoms may be much reduced.
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Routine Vaccination Of People 50 Years Old And Older
CDC recommends Shingrix for the prevention of herpes zoster and related complications. CDC recommends two doses of Shingrix separated by 2 to 6 months for immunocompetent adults aged 50 years and older:
- Whether or not they report a prior episode of herpes zoster.
- Whether or not they report a prior dose of Zostavax, a shingles vaccine that is no longer available for use in the United States.
- It is not necessary to screen, either verbally or by laboratory serology, for evidence of prior varicella.
Recombinant and adjuvanted vaccines, such as Shingrix, can be administered concomitantly, at different anatomic sites, with other adult vaccines, including COVID-19 vaccines. Coadministration of RZV with adjuvanted influenza vaccine and COVID-19 vaccines is being studied.
Cdc Recommendation For The Shingles Vaccine
The Centers for Disease Control and Prevention recommend Shingrix as the preferred vaccine to prevent shingles and other complications from the disease.
The CDC found that Shingrix was more effective than Zostavax. It recommends that you receive Shingrix, even if youve had Zostavax in the past.
The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to suit your needs.
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What Everyone Should Know About The Shingles Vaccine
Shingles vaccination is the only way to protect against shingles and postherpetic neuralgia , the most common complication from shingles.
CDC recommends that adults 50 years and older get two doses of the shingles vaccine called Shingrix to prevent shingles and the complications from the disease. Adults 19 years and older who have weakened immune systems because of disease or therapy should also get two doses of Shingrix, as they have a higher risk of getting shingles and related complications.
Your doctor or pharmacist can give you Shingrix as a shot in your upper arm.
Shingrix provides strong protection against shingles and PHN. In adults 50 years and older who have healthy immune systems, Shingrix is more than 90% effective at preventing shingles and PHN. Immunity stays strong for at least the first 7 years after vaccination. In adults with weakened immune systems, studies show that Shingrix is 68%-91% effective in preventing shingles, depending on the condition that affects the immune system.
Who Shouldnt Get The Shingles Vaccine
You shouldnt receive the shingles vaccine if:
- Youve had a previous severe allergic reaction to Shingrix or any of its ingredients.
- Youre pregnant or breastfeeding.
- You have no immunity to chickenpox, which means you should get the chickenpox vaccine instead.
Having a mild illness like a cold isnt a reason to not get your shingles vaccine.
However, if you have a moderate to severe illness or a fever of 101.3 or higher, you should recover before getting your shingles vaccine.
state that the COVID-19 vaccine may be given without regard to the timing of other vaccines.
This means you dont have to wait to receive your COVID-19 and shingles vaccinations.
In fact, you can get your COVID-19 vaccine and shingles vaccine at the same time. If you choose to do this, make sure to receive your injections at two different sites.
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Cdc Shingles Vaccine Recommendations
The Centers for Disease Control and Prevention recommends Shingrix vaccination for everyone 50 years and older and those 19 years and older who have weakened immune systemseven if you have already had shingles, if you had another type of shingles vaccine, and if you dont know whether or not youve had chickenpox in the past.
You should not get the vaccine if you have a severe allergy to any of the components, currently have shingles, or you have lab tests that definitively show that you do not have antibodies against the varicella-zoster virus. In that case, you may be better off getting the varicella vaccine instead. Also, those who are pregnant should consider delaying vaccination with Shingrix until after delivery.
What Is The Shingles Vaccine
The shingles vaccine can protect you against shingles and postherpetic neuralgia , which is the most common complication of shingles. Shingles is a painful rash caused by the varicella-zoster virus, the same virus that causes chickenpox. The rash usually develops on one side of your body or face. It starts with red bumps and then the bumps turn into fluid-filled blisters.
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Are There Alternatives To Shingrix
Shingrix is the only shingles vaccine thats currently available in the U.S. This version of the vaccine only contains a portion of the virus that causes shingles.
Before November 2020 there was another shingles vaccine Zostavax that contained a weakened form of the virus. It is only 50% effective at preventing shingles.
Zostavax is still offered in other countries. For the most part, its only used if youve previously had a life-threatening reaction to something in Shingrix.
Who Cannot Get Shingrix Vaccine
- Medical Reviewer: Dany Paul Baby, MD
Medically Reviewed on 5/26/2022
Shingrix is the most common shingles vaccine thats in use today. This is, most likely, the vaccine that your doctor will recommend for shingles when you live in the U.S.
Who is a candidate for the shingles vaccine, and who isnt? There are only a few situations when you shouldnt get Shingrix. You cannot get Shingrix if:
- You currently have an active shingles infection particularly if you still have a rash
- Youve had the chickenpox vaccine within the past eight weeks
- Youve had a severe allergic reaction like anaphylaxis to any part of the Shingrix vaccine or your first dose of Shingrix
- Youre currently pregnant
You also shouldnt get Shingrix if youve had a shingles vaccine called Zostavax within the past eight weeks. This isnt likely unless you were vaccinated outside of the United States. Zostavax hasnt been used in the U.S. since November 2020.
Keep in mind that theres only data on patients who have safely taken Shingrix five years after Zostavax. The Centers for Disease Control and Prevention recommend this shorter wait time because its highly unlikely that the two vaccines are dangerous when combined.
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Do I Need To Pay For Shingles Immunisation
Vaccines covered by the NIP are free for people who are eligible. See the NIP Schedule to find out which vaccines you or your family are eligible to receive.
Eligible people get the vaccine for free, but your health care provider may charge a consultation fee for the visit. You can check this when you make your appointment.
If you are not eligible for free vaccine, you may need to pay for it. The cost depends on the type of vaccine, the formula and where you buy it from. Your immunisation provider can give you more information.
For Patients Who Do Not Report A Prior Episode Of Varicella
When vaccinating immunocompetent adults aged 50 years and older, there is no need to screen for a history of varicella or to conduct laboratory testing for serologic evidence of prior varicella. More than 99% of adults aged 50 years and older worldwide have been exposed to varicella-zoster virus, and the Advisory Committee on Immunization Practices considers people born in the United States prior to 1980 immune to varicella. Therefore, even if a person does not recall having chickenpox, serologic testing for varicella immunity is not recommended. It is often a barrier to herpes zoster vaccination, and false negatives are common. However, if serologic evidence of varicella susceptibility becomes available to the healthcare provider, providers should follow ACIP guidelines for varicella vaccination. Shingrix has not been evaluated in persons who are seronegative to varicella, and it is not indicated for the prevention of varicella.
For adults 19 years of age and older who are or will be immunocompromised, see .
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Prior Vaccination With Zoster Vaccine Live
Grupping et al. performed a phase 3, open-label, group-matched, non-inferiority, multicenter study in adults aged 65 or older, previously vaccinated with ZVL within five years or more and matched to adults who were ZVL-naïve .11 Participants received two IM doses of HZ/su two months apart. Patients were excluded if they had received a live vaccine within 30 days or any investigational drug or vaccine within 30 days, were on any immunosuppressants or immune-modifying drugs within a specific timeframe, or had a history of herpes zoster. The primary study objectives were to compare the noninferiority of humoral immune responses one month after the second HZ/su dose between the HZ-PreVac and HZ-NonVac groups, and to evaluate the safety and reactogenicity up to one month after the second dose of HZ/su in both groups. Noninferiority of the humoral immune response was determined if the upper limit of the 95% CI of the adjusted anti-gE geometric mean concentration ratio of HZ-NonVac over HZ-PreVac was < 1.5.11
In 430 participants, the humoral immune response to HZ/su was non-inferior in the HZ-PreVac group compared with the HZ-NonVac group . There were also no differences seen in CD4+ T cells between the groups. The study showed that HZ/su elicits a strong immune response regardless of prior ZVL vaccination.11