When Should I Expect A Fever To Appear After Vaccination
Most fevers occur within a week of vaccination however, because vaccines cause immunity in different ways, depending on how they are made, there is some variation regarding exactly when fevers following vaccination are most likely to occur. Additionally, because some vaccines require more than one dose to be effective, fevers may be more likely after later doses. The timing and frequency of fevers after many common vaccines are listed below.
What Is This Medicine
MENINGOCOCCAL GROUP B VACCINE, RECOMBINANT is a vaccine to protect from bacterial meningitis. This vaccine does not contain live bacteria. It will not cause a meningitis.
They need to know if you have any of these conditions:-bleeding disorder-an unusual or allergic reaction to meningococcal vaccine, other medicines, foods, dyes, or preservatives-pregnant or trying to get pregnant-breast-feeding
This medicine is for injection into a muscle. It is given by a health care professional in a hospital or clinic setting.A copy of Vaccine Information Statements will be given before each vaccination. Read this sheet carefully each time. The sheet may change frequently.Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years of age for selected conditions, precautions do apply.
What If There Is A Serious Reaction
An allergic reaction could occur after the vaccinated person leaves the clinic. If you see signs of a severe allergic reaction , call 9-1-1 and get the person to the nearest hospital.
For other signs that concern you, call your health care provider.
Adverse reactions should be reported to the Vaccine Adverse Event Reporting System . Your health care provider will usually file this report, or you can do it yourself. Visit the VAERS website at or call . VAERS is only for reporting reactions, and VAERS staff does not give medical advice.
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Why Do Vaccines Cause Fevers
Vaccines prepare the immune system to protect against viruses or bacteria that could make people sick. The way this happens is that they introduce components of the germs that are known to activate the immune response. However, the vaccine is made in a way that it will not cause a significant enough immune response that the person becomes ill. But, in some cases the immune response is strong enough to cause detectable symptoms, like a mild fever. It is important to realize, though, that a lack of detectable fever, or other side effects, does not mean that the vaccine was not effective.
Why Is The Meningitis B Vaccine Not Recommended As Strongly As The Ac W Y Vaccine
In short: cost. Dr. Tan says theres a problem with formally recommending a meningitis B vaccination for every young person in the US. Were not infinitely rich. The resources to vaccinate every adolescent in our countryits immense. Its just not practical, he explains.
That said, the current recommendation isnt working either.
Weve got to figure out a way to manage this. Were depriving people of a very good vaccine who might want to get protected, Dr. Tan says. He places the blame on doctors who dont bring up the disease or the vaccine when they meet with their patients. Thats an implementation problem. If you fail to talk about B vaccine, youre failing your patients. need to have an internal policy where everybody agrees youre going to talk about the vaccine, Dr. Tan says.
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Use In Specific Populations
Pediatric Use: Safety and effectiveness have not been established in children < 10 years of age. In a clinical study, 90% of infants < 12 months of age who were vaccinated with a reduced dosage formulation had fever.
See 17 for PATIENT COUNSELING INFORMATION.
For intramuscular use only.
Problems That Could Happen After Getting Any Injected Vaccine
- People sometimes faint after medical procedures, including vaccination. Sitting or lying down for about 15 minutes can help prevent fainting, and injuries caused by a fall. Tell the provider if you or your child feel dizzy, have vision changes, or have ringing in the ears.
- As with any medicine, there is a very remote chance of a vaccine causing a severe allergic reaction, other serious injury, or death.
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If You Are Given Too Much
An overdose is highly unlikely, as it is given as a single-dose syringe by a doctor or nurse.
If the doses are given closer together than recommended or more doses than required are given, side effects are more likely to occur.
Immediately telephone your doctor or Poisons Information Centre for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have been given too much Trumenba.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
How To Use Trumenba Syringe
This vaccine is given by injection into a muscle by a health care professional. Adults and children usually receive the injection in the upper arm, and infants receive it in the upper thigh. Depending on your age, the vaccine is given one or more times. Ask your health care professional for your recommended vaccine schedule.
Since fever may commonly occur after vaccination , your health care professional may recommend a fever/pain relief medication for use if needed. Ask your health care professional for details.
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Investigating The Immunogenicity Of A Us
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|First Posted : October 7, 2015Results First Posted : February 2, 2021Last Update Posted : February 2, 2021|
- Study Details
|Biological: Trumenba Vaccine||Phase 4|
|Study Type :|
|Official Title:||Immunogenicity of a U.S.-Licensed Meningococcal Serogroup B Vaccine in Adults at Increased Risk of Meningococcal Disease Because of Occupational Exposure|
|Actual Study Start Date :|
|Trumenba Meningococcal Group B Vaccine||Biological: Trumenba Vaccine All subjects will receive three doses of a Trumenba, a U.S.-licensed meningococcal vaccine. Each 0.5 mL dose contains 60 micrograms of each FHbp variant , 0.018 mg of PS80 and 0.25 mg of Al³+ as AlPO4 in 10 mM histidine buffered saline at pH 6.0. Trumenba is administered as a three dose series according to a 0-, 2-, and 6-month schedule.Other Name: MenB-FHbp|
You Are Pregnant Or Breastfeeding
- Pregnant women who are at increased risk for serogroup A, C, W, or Y meningococcal disease may get MenACWY vaccines.
- Pregnant or breastfeeding women who are at increased risk for serogroup B meningococcal disease may get MenB vaccines. However, they should talk with a doctor to decide if the benefits of getting the vaccine outweigh the risks.
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Trumenba Study Among Students
The purpose of the TruSS research study is to better understand the immune response to Trumenba® vaccine. Trumenba® vaccine was licensed in the US in 2014 and is available at health clinics to help protect teens and young adults against meningococcal disease caused by group B .
Meningococcal disease is a relatively rare but serious bacterial infection that can lead to lifelong complications, and even death, and young adults are at increased risk.
Since 2011, all meningococcal outbreaks that occurred on college campuses were caused by Men B.
We are conducting this study because we want to learn more about the immune response to this vaccine to better prevent outbreaks and protect young adults in the future.
You may be eligible for this study if:
- You are 18 -23 years old at the time of enrollment.
- You are currently enrolled as an undergraduate student at the UMN and anticipate being on campus for the current and following semesters.
- You have not previously received any MenB vaccines.
- You do not have an illness or condition that makes giving a blood sample inadvisable.
- Everyone in the study will complete two in-person study visits over seven months.
- During these visits, you will complete a questionnaire, give a copy of your vaccination records, and give a small sample of blood.
Two Different Vaccines Are Needed To Fully Vaccinate Your Teen Or Young Adult Against Meningitis
There are 5 primary types of bacteria that cause meningitis and for which vaccines are available in the US: A, C, W, Y, and B.8
The Centers for Disease Control and Prevention recommends vaccination for types A, C, W, and Y at ages 11 to 12 , and a booster at age 16. The CDC recommends deciding with your doctor about vaccinating your child against MenB. The CDC-recommended age for MenB vaccination is 16 to 23 years .9,10
You can help protect your teen by vaccinating with TRUMENBA, which is FDA approved for MenB.1
Routine visits with your child’s doctor are a good opportunity to discuss the risks and potential serious side effects of MenB.7 Make sure you know whether your teen has received both types of meningitis vaccines, and whether they are protected against MenB.
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What Is Meningococcal Group B Vaccine
Meningococcal disease is a serious infection caused by a bacteria. Meningococcal bacteria can infect the spinal cord and brain, causing meningitis that can be fatal. Meningococcal disease can also lead to permanent and disabling medical problems.
Meningococcal disease can spread from one person to another through small droplets of saliva released into the air when an infected person coughs or sneezes. The bacteria can also live on things the infected person has touched, such as a door handle or other surface. The bacteria can also be passed through kissing, or sharing a drinking glass or eating utensil with an infected person.
Meningococcal disease is more likely to occur in babies younger than 1 year, in young people ages 16 to 23 years, in anyone with a weak immune system, and in anyone exposed to an outbreak of the disease.
Meningococcal group B vaccine is used to prevent infection caused by serogroup B meningococcal bacteria. This vaccine contains four common strains of group B meningococcal bacteria.
This vaccine helps your body develop immunity to meningitis, but will not treat an active infection you already have.
Meningococcal group B vaccine is for use in children and young adults who are 10 to 25 years old. The Centers for Disease Control recommends that the best time to get this vaccine is between the ages of 16 and 18 years old.
Like any vaccine, the meningococcal group B vaccine may not provide protection from disease in every person.
What Are The Possible Side Effects Of This Vaccine
Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shot caused any side effects.
You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.
Becoming infected with meningococcal disease and developing meningitis is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.
You may feel faint after receiving this vaccine. Some people have had seizure-like reactions after receiving this vaccine. Your doctor may want you to remain under observation during the first 15 minutes after the injection.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1 800 822 7967.
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Simultaneous Administration With Other Vaccines
Men-C-C and 4CMenB vaccine may be administered concomitantly with routine childhood vaccines, and Men-C-ACYW vaccine may be administered concomitantly with adolescent and adult age appropriate vaccines. MenB-fHBP can be given concomitantly with quadrivalent human papillomavirus vaccine meningococcal serogroup A, C, Y, W conjugate vaccine and tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine adsorbed. The concomitant administration of MenB-fHBP has not been studied with other vaccines.
Men-C-ACYW-CRM can be administered with routine paediatric vaccines however, further studies are needed with regard to concomitant administration with pneumococcal 13-valent conjugate vaccine. Co-administration of Men-C-ACYW-CRM and combined tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine may result in a lower immune response to the pertussis antigens than when Tdap vaccine is given alone however, the clinical significance of this is unknown. Tdap vaccine given one month after Men-C-ACYW-CRM induces the strongest immunologic response to pertussis antigens.
If vaccines are to be administered concomitantly with another vaccine, a separate injection site and a different syringe must be used for each injection.
Refer to Timing of Vaccine Administration in Part 1 for additional general information.
Princeton Public Health Review
Last Wednesday, the FDA approved a vaccine for Meningitis B1,2, the same strain of bacterial meningitis that Princeton students faced last year. Yet the newly-approved drug is not Novartis Bexsero, which thousands of students at Princeton and UCSB have received in the past year. Instead, the FDA approved Pfizers Trumenba. This forces us to wonder why the FDA decided to approve Trumenba first, even though Bexsero has now been used safely and effectively in the United States and is approved in Canada, Europe, and Australia3.
The most straightforward explanation for the earlier approval of Trumenba is that Pfizer filed for approval before Novartis4. Yet another possible factor for the approval of Trumenba over Bexsero could be that Bexsero is not considered to be cost-effective5. This idea was spread by the UK Joint Committee on Vaccination and Immunisation , which revealed that Bexsero may not protect those vaccinated for long enough to be worth the current cost of the vaccination. Also, those who are vaccinated can still act as Meningitis B carriers. So while two doses of the vaccine can make an individual immune, this vaccination does not guarantee that the disease will not be transmitted to others, making it less effective than public health officials would hope. While Bexsero was effective at Princeton and UCSB, the JCVI still deemed that it is not cost-effective at market price, thus perhaps influencing the FDA choose Trumenba instead.
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Why Do Teens Need A Meningococcal Vaccine
Of the 1,000-2,600 people who get meningococcal disease each year, one-third are teens and young adults. Ten percent to 15% of those who get sick with the disease will die, even with antibiotic treatment. As many as 20% of the survivorswill have permanent side effects, such as hearing loss or brain damage.
The immunization can help prevent this serious disease.
Before Taking This Medicine
You should not receive this vaccine if you’ve ever had an allergic reaction to Trumenba.
This vaccine may need to be postponed or not given at all if you have:
an allergy to latex rubber
a severe illness with a fever or any type of infection or
a weak immune system caused by disease or by using certain medicine .
You can still receive a vaccine if you have a minor cold.
Your doctor should determine whether you need this vaccine during pregnancy or while breastfeeding.
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Persons New To Canada
Health care providers who see persons newly arrived in Canada should review the immunization status and update immunization for these individuals. Review of meningococcal vaccination status is particularly important for persons from areas of the world where sickle cell disease is present as persons with sickle cell disease are at risk of serious meningococcal infections. In many countries outside of Canada, conjugate meningococcal vaccines are in limited use. Information on vaccination schedules in other countries can be found on the World Health Organization website. Refer to Immunization of Persons New to Canada in Part 3 for additional general information.
Vaccines Against Multiple Pathogens
- MMR II®, 0 to 14 days after vaccination in 2 of 100 vaccine recipients
- Daptacel®, 0 to 3 days after vaccination in 11-20 of 100 vaccine recipients
- Infantrix®, 0 to 4 days after vaccination in 8-12 of 100 vaccine recipients fevers occur more frequently after the second dose
DTaP combined with other components
- Plus polio – Quadracel®, 0 to 7 days after vaccination in 6 of 100 vaccine recipients
- Plus polio and Hib – Pentacel®, 0 to 3 days after vaccination in 6-16 of 100 vaccine recipients
- Plus polio and hepatitis B – Pediarix®, 0 to 4 days after vaccination in 28-39 of 100 vaccine recipients
- Boostrix®, 0 to 15 days after vaccination in 19 of 100 vaccine recipients
- Adacel®, 0 to 15 days after vaccination in 1-5 of 100 vaccine recipients fevers occur more frequently in children than adults
Hepatitis A and hepatitis B
- Twinrix®, 0 to 4 days after vaccination in 2-4 of 100 vaccine recipients
Hib and meningitis CY
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